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Further exploration found that for AAs with T2DM, renal apolipoprotein L1 (APOL1) risk variants were associated with decreased cerebral WML volume and larger GM volume (125), although the association between APOL1 risk variants and changes in cognitive function remains unclear

It also improved the proliferative and secretory functions of fibroblasts and reversed morphological abnormalities of senescent cells (such as flattened cell shape, enlarged volume, and nuclear pyknosis)